“A Disk Read Error Occurred. Press CTRL+ALT+DEL to restart”
or
“Error Loading Operating System”
This is only one solution because this problem can be caused many reasons.
My symptoms were that I had to restart my computer multiple times after Post-Bios until I could finally start into Windows. Inside Windows, it sometimes locked up when the Hard Drive was under heavy use. I exchanged the cables but it did nothing. Now today I unplugged the Slave Drive and it worked! My Primary Hard Drive (Master) hosts the Operating System and the Secondary Hard Drive (Slave) as a file reservoir. It seems that the Secondary Hard Drive (since they share one cable) did not properly pass the data through the cable from my Primary Hard Drive to the Motherboard. Try it out for yourself!
This only applies to IDE systems, not SATA.
Not to mention this is just one cause out of a thousand.